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  • Title: Symmetrical and asymmetrical cyanine dyes. Synthesis, spectral properties, and BSA association study.
    Author: Pisoni DS, Todeschini L, Borges AC, Petzhold CL, Rodembusch FS, Campo LF.
    Journal: J Org Chem; 2014 Jun 20; 79(12):5511-20. PubMed ID: 24845528.
    Abstract:
    New cyanines were prepared by an efficient and practical route with satisfactory overall yield from low-cost starting materials. The photophysical behavior of the cyanines was investigated using UV-vis and steady-state fluorescence in solution, as well as their association with bovine serum albumin (BSA) in phosphate buffer solution (PBS). No cyanine aggregation was observed in organic solvents or in phosphate buffer solution. The alkyl chain length in the quaternized nitrogen was shown to be fundamental for BSA detection in PBS in these dyes.
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