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  • Title: The effect of intrathecal galanin on the flexor reflex in rat: increased depression after sciatic nerve section.
    Author: Wiesenfeld-Hallin Z, Xu XJ, Villar MJ, Hökfelt T.
    Journal: Neurosci Lett; 1989 Oct 23; 105(1-2):149-54. PubMed ID: 2484726.
    Abstract:
    The effect of intrathecal galanin (GAL) on the hamstring flexor reflex to sural nerve stimulation was compared in rats with intact and unilaterally sectioned sciatic nerves. GAL had a biphasic effect on the flexor reflex in rats with intact nerves, including facilitation, facilitation followed by depression and pure depression, in a dose-dependent manner. In axotomized rats, the depressive effect of GAL was significantly increased, occurring at lower drug concentrations. Furthermore, the degree of depression was significantly stronger with a more rapid onset after nerve section. It is concluded that along with an increase in GAL-like immunoreactivity in primary afferents, the inhibitory function of this neuropeptide is enhanced following axotomy. This functional change may be due to both pre- and postsynaptic mechanisms.
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