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  • Title: Hyafurones, hyapyrrolines, and hyapyrones: polyketides from Hyalangium minutum.
    Author: Okanya PW, Mohr KI, Gerth K, Kessler W, Jansen R, Stadler M, Müller R.
    Journal: J Nat Prod; 2014 Jun 27; 77(6):1420-9. PubMed ID: 24848583.
    Abstract:
    Seven new polyketides, for which the trivial names hyafurones A1-B (1-3), hyapyrrolines A (4) and B (5), and hyapyrones A (6) and B (7) are proposed, were isolated from the fermentation broth of the myxobacteria Hyalangium minutum, strains NOCB-2(T) and Hym-3. Their structures were elucidated from NMR and HRESIMS data, and their geometric configuration was assigned based on NOE and vicinal (1)H coupling data. Both hyafurone B (3) and hyapyrone B (7) inhibited growth of the Gram-positive bacterium Nocardia flava, while 7 showed antifungal activity against Mucor hiemalis.
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