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  • Title: Ergosterol reverses multidrug resistance in SGC7901/Adr cells.
    Author: Hu X, Jiang D, Li F, Wu Z, Huang Y, Song S, Wang Z.
    Journal: Pharmazie; 2014 May; 69(5):396-400. PubMed ID: 24855835.
    Abstract:
    Multidrug resistance (MDR) is a major obstacle in the chemotherapeutic treatment of tumors. Elevated expression of the P-glycoprotein (P-gp) transporter is associated with MDR and responsible for the resistance of tumor cells against a variety of anticancer drugs. In this study, the reversal effect of ergosterol (Erg) on SGC7901/Adr cells was investigated. At concentrations of 1 microM and 5 microM, Erg could reverse the resistance of SGC7901/Adr to adriamycin up to 4.84 and 3.92 folds, respectively. Mechanistically, Erg could increase the intracellular accumulation of adriamycin and Rh123 in SGC7901/Adr cells through inhibiting the transcription of MDR1 gene and down-regulating the expression of P-gp. In conclusion, Erg could reverse the MDR of SGC7901/Adr cells via its influence on P-gp expression and thus be a promising lead compound for future studies.
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