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  • Title: [Familial adenomatous polyposis:a report of 10 cases in 3 generations of a family and literature review].
    Author: Nie Y, Zhang R, Fan K, Liang H.
    Journal: Zhonghua Nei Ke Za Zhi; 2014 Apr; 53(4):290-2. PubMed ID: 24857303.
    Abstract:
    OBJECTIVE: To investigate the clinical characteristic, diagnosis and treatment of familial adenomatous polyposis (FAP). METHODS: According to family history of the proband, we surveyed the pedigree and retrospectively analyzed the clinical characteristics of 10 FAP patients in 3 generations of the family. RESULT: Among all 10 cases, 3 died of colorectal cancer including two of whom had history of intestinal obstruction.Seven people of the third generation were all diagnosed as FAP. Among them, only 2 patients had clinical symptoms. Colonoscopy was done in all 7 patients before 35 years old. However, none of them had polyps or evidence of cancer.Surgical operation was performed on 1 patient and high frequency electric cutting under endoscopy was performed on 6 patients. CONCLUSIONS: The early clinical manifestations of FAP are nonspecific. Pedigree investigation and colonoscopy screening for high-risk population are important to find early asymptomatic FAP patients.
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