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  • Title: Multimeric grain-marked micelles for highly efficient photodynamic therapy and magnetic resonance imaging of tumors.
    Author: Lee UY, Oh YT, Kim D, Lee ES.
    Journal: Int J Pharm; 2014 Aug 25; 471(1-2):166-72. PubMed ID: 24858385.
    Abstract:
    Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to the surface of the core micelle (multi-maleimide functionalized micelle). These micelles enable discrete compartments for Ce6 and iron oxide (Fe3O4) that enable a significantly increased in vivo photodynamic tumor inhibition while preserving high contrast magnetic resonance (MR) imaging of the tumor in vivo.
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