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  • Title: Intracranial tuberculomas. An assessment of a therapeutic 4-drug trial in 35 children.
    Author: Domingo Z, Peter JC.
    Journal: Pediatr Neurosci; 1989; 15(4):161-6; discussion 166-7. PubMed ID: 2485910.
    Abstract:
    35 children with suspected tuberculomas of the brain were given a therapeutic 4-drug trial of isoniazid, rifampicin, pyrazinamide and ethambutol. Their clinical and computed tomographic (CT) appearances were analysed retrospectively: 32 responded well to treatment with recognizable improvement on CT after 6 weeks. Three patients did not respond. One of these non-responders had a surgically removed temporal cystic astrocytoma. The majority presented with focal seizures and had a single hemispheral lesion. 14% had multiple lesions, 6% were in the cerebellum. Only 2 patients had raised intracranial pressure and required ventriculoperitoneal shunting.
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