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  • Title: Disseminated BCG in an infant with interleukin-12 receptor B1 (IL12RB1) deficiency.
    Author: Senanayake MP, Kumararatne DS, Doffinger R, Barcenas-Morales G.
    Journal: Paediatr Int Child Health; 2015 Feb; 35(1):69-71. PubMed ID: 24863105.
    Abstract:
    Although neonatal vaccination with bacille Calmette-Guérin (BCG) is considered to be safe, complications with disseminated disease are associated with underlying immuno-deficiency disorders. A BCG-vaccinated 4-month-old girl of Sri Lankan parentage developed progressive left axillary lymphadenopathy and severe bronchopneumonia. Lymph node biopsy demonstrated epithelioid granulomata and acid-fast bacilli. An older sibling had had a similar clinical presentation and the outcome had been fatal. Investigation for immuno-deficiency detected complete IL12RB1 deficiency. Full recovery followed a prolonged course of anti-tuberculous chemotherapy. She was put on lifelong isoniazid prophylaxis. In HIV-negative infants with unusual complications related to BCG vaccination, a primary immuno-deficiency disorder should be considered.
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