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  • Title: [Role of the RIG-I-like receptors in antiviral response].
    Author: Jabłońska A, Paradowska E.
    Journal: Postepy Hig Med Dosw (Online); 2014 Jan 02; 68():541-56. PubMed ID: 24864105.
    Abstract:
    The innate nonspecific immunity is the first line of defense against viral infection. Toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are two main receptor families detecting viral nucleic acid. So far, three RLR family members were characterized: RIG-I, MDA5 and LGP2. RLR constitute a family of cytoplasmic helicases, which recognized intracellular single-stranded and double-stranded RNA that is introduced to cytosol during viral infection and replication. In this work we review the current knowledge about the mechanisms of viral recognition by RIG-I-like receptors and their signaling pathways for the activation of type I interferons and pro-inflammatory cytokines synthesis.
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