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  • Title: Sucrose/Glucose molecular alloys by cryomilling.
    Author: Megarry AJ, Booth J, Burley J.
    Journal: J Pharm Sci; 2014 Jul; 103(7):2098-2106. PubMed ID: 24867316.
    Abstract:
    We report here for the first time a series of amorphous sucrose/glucose molecular alloys prepared by cryomilling. Differential scanning calorimetry, X-ray powder diffraction and solution proton nuclear magnetic resonance showed that cryomilling drives a direct transformation from a two-phase mixture of crystalline sucrose and glucose, to a single-phase amorphous sucrose/glucose molecular alloy. The molecular alloys displayed a single Tg which varied linearly with composition. The effect of atmospheric moisture and the possibility of localised melting of the material because of milling-related friction were also discussed.
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