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  • Title: Asymmetric and symmetric dimethylarginine are associated with coronary artery lesions in Kawasaki disease.
    Author: Huang YH, Tain YL, Lee CP, Kuo HC.
    Journal: J Pediatr; 2014 Aug; 165(2):295-9. PubMed ID: 24874168.
    Abstract:
    OBJECTIVE: To determine whether 3 biomarkers, L-arginine, asymmetric dimethylarginine (ADMA), and symmetric dimethylarginine (SDMA), can predict outcomes in patients with Kawasaki disease (KD). STUDY DESIGN: Plasma levels of L-arginine, ADMA, and SDMA were measured in 39 patients with KD and 27 febrile control patients. RESULTS: Plasma L-arginine, ADMA, and SDMA levels were lower in patients with KD than in control patients before treatment with intravenous immunoglobulin (IVIG; P=.027, P<.001, and P<.001, respectively). After treatment with IVIG, L-arginine, ADMA, L-arginine/ADMA ratios, and arginine methylation ([ADMA+SDMA]/L-arginine) increased significantly (P<.001, P=.001, P=.014, and P=.001, respectively). Compared with control patients, persistent lower SDMA and higher ADMA/SDMA ratios existed in patients with KD. Furthermore, a lesser magnitude of change in terms of L-arginine and ADMA/SDMA ratios after IVIG treatment was associated with the formation of coronary dilation (P=.025, and .029, respectively). CONCLUSION: Levels of L-arginine, ADMA, and SDMA appear to be associated with KD. Lower L-arginine levels and ADMA/SDMA after treatment with IVIG was associated with coronary artery abnormalities patients with KD.
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