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  • Title: Antigen-specific B-cell response to 13-valent pneumococcal conjugate vaccine in asplenic individuals with β-thalassemia previously immunized with 23-valent pneumococcal polysaccharide vaccine.
    Author: Papadatou I, Piperi C, Alexandraki K, Kattamis A, Theodoridou M, Spoulou V.
    Journal: Clin Infect Dis; 2014 Sep 15; 59(6):862-5. PubMed ID: 24879786.
    Abstract:
    Current guidelines recommend a combined schedule of a 13-valent pneumococcal conjugate vaccine (PCV13) and PPSV23 (23-valent polysaccharide vaccine) for asplenic individuals. We show that PCV13 induces a T-dependent immune response in asplenic individuals with β-thalassemia, but previous PPSV23s affect the memory B-cell response in a dose- and time-dependent manner. Clinical Trials Registration. NCT01846923.
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