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  • Title: Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance.
    Author: Kodama T, Tsukaguchi T, Yoshida M, Kondoh O, Sakamoto H.
    Journal: Cancer Lett; 2014 Sep 01; 351(2):215-21. PubMed ID: 24887559.
    Abstract:
    The clinical efficacy of the ALK inhibitor crizotinib has been demonstrated in ALK fusion-positive NSCLC; however, resistance to crizotinib certainly occurs through ALK secondary mutations in clinical use. Here we examined the efficacy of a selective ALK inhibitor alectinib/CH5424802 in models of crizotinib resistance. Alectinib led to tumor size reduction in EML4-ALK-positive xenograft tumors that failed to regress fully during the treatment with crizotinib. In addition, alectinib inhibited the growth of some EML4-ALK mutant-driven tumors, including the G1269A model. These results demonstrated that alectinib might provide therapeutic opportunities for crizotinib-treated patients with ALK secondary mutations.
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