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  • Title: Enchondroma of the nasal septum due to Ollier disease: a case report and review of the literature.
    Author: Jacobi CM, Hiranya ES, Gay A, Holzmann D, Kollias S, Soyka MB.
    Journal: Head Neck; 2015 Mar; 37(3):E30-3. PubMed ID: 24890303.
    Abstract:
    BACKGROUND: Morbus Ollier is characterized by the presence of multiple enchondromas (ie, benign intraosseous cartilaginous lesions). Although their manifestation in the limb bones is well described, only a few cases with ear, nose, and throat (ENT) involvement, primarily arising from the skull, have been reported. The malignant transformation toward slowly growing low-grade chondrosarcomas is the most severe form of progression. METHODS: We report a unique case of a 54-year-old patient with Ollier disease with an extensive nasal enchondroma apparently eroding the middle nasal concha and expanding to the lateral nasal wall that raised suspicion of malignant transformation. RESULTS: Radiological and histological features of enchondromas can be controversial and seem to have limited sensitivity to exclude low-grade malignancy. The clinical symptoms play a decisive role in differentiation between enchondromas and low-grade chondrosarcomas. CONCLUSION: Surgery remains the only effective solution in removing an enchondroma and preventing the tendency toward malignant transformation.
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