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  • Title: A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis.
    Author: Shin JM, Kim SH, Thambi T, You DG, Jeon J, Lee JO, Chung BY, Jo DG, Park JH.
    Journal: Chem Commun (Camb); 2014 Jul 21; 50(57):7632-5. PubMed ID: 24893961.
    Abstract:
    In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
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