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  • Title: Aerogel microspheres from natural cellulose nanofibrils and their application as cell culture scaffold.
    Author: Cai H, Sharma S, Liu W, Mu W, Liu W, Zhang X, Deng Y.
    Journal: Biomacromolecules; 2014 Jul 14; 15(7):2540-7. PubMed ID: 24894125.
    Abstract:
    We demonstrated that ultralight pure natural aerogel microspheres can be fabricated using cellulose nanofibrials (CNF) directly. Experimentally, the CNF aqueous gel droplets, produced by spraying and atomizing through a steel nozzle, were collected into liquid nitrogen for instant freezing followed by freeze-drying. The aerogel microspheres are highly porous with bulk density as low as 0.0018 g cm(-3). The pore size of the cellulose aeogel microspheres ranges from nano- to macrometers. The unique ultralight and high porous structure ensured high moisture (~90 g g(-1)) and water uptake capacity (~100 g g(-1)) of the aerogel microspheres. Covalent cross-linking between the native nanofibrils and cross-linkers made the aerogel microspheres very stable even in a harsh environment. The present study also confirmed this kind of aerogel microspheres from native cellulose fibers can be used as cell culture scaffold.
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