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  • Title: Cytotoxic aryltetralin lignans from fruits of Cleistanthus indochinensis.
    Author: Trinh Thi Thanh V, Pham VC, Doan Thi Mai H, Litaudon M, Guéritte F, Nguyen VH, Chau VM.
    Journal: Planta Med; 2014 Jun; 80(8-9):695-702. PubMed ID: 24896244.
    Abstract:
    Eight new aryltetralin lignans, cleisindosides A-F (1-6), picroburseranin (7), and 7-hydroxypicropolygamain (8), were isolated from the fruits of Cleistanthus indochinensis (Euphorbiaceae). The structures of the isolates were established on the basis of their one- and two-dimensional NMR spectral data, as well as their mass spectrometric data. Compound 7 was found to have potent cytotoxicity against oral epidermoid carcinoma cells with an IC50 value of 0.062 µM, whereas glycosylation to 3 (IC50 7.5 µM) and stereochemical changes to 8 (IC50 10.8 µM) led to marked decreases in biological activity. Thus, it was determined that the C-7 and C-8' positions are critical for the biological activity of the lignans from this plant.
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