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  • Title: Rapid progression of pleural disease due to exposure to Libby amphibole: "Not your grandfather's asbestos related disease".
    Author: Black B, Szeinuk J, Whitehouse AC, Levin SM, Henschke CI, Yankelevitz DF, Flores RM.
    Journal: Am J Ind Med; 2014 Nov; 57(11):1197-206. PubMed ID: 24898907.
    Abstract:
    BACKGROUND: Residents and mine employees from Libby, Montana, have been exposed to asbestiform amphiboles from the vermiculite mine that operated in this location from the mid-1920s until 1990. Clinical observations show a different form of asbestos-related toxicity than other forms of asbestos. METHODS: Five illustrative cases from the Center for Asbestos-Related Diseases in Libby were selected. All had clear exposure histories, multiple follow-up visits, illustrative chest radiographic studies, serial pulmonary function tests, and sufficient length of follow-up to characterize disease progression. RESULTS: These cases developed increasing symptoms of dyspnea and chest pain, progressive radiological changes that were predominantly pleural, and a restrictive pattern of impaired spirometry that rapidly progressed with significant loss of pulmonary function. CONCLUSIONS: LA exposure can cause a non-malignant pleural disease that is more rapidly progressive and more severe than the usual asbestos-related disease.
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