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  • Title: Diffuse Myocardial Uptake of (99m)Tc-HDP in Multiple Myeloma.
    Author: Demirel K, Sadic M, Korkmaz M, Comak A, Atilgan HI, Koca G.
    Journal: Nucl Med Mol Imaging; 2013 Sep; 47(3):208-11. PubMed ID: 24900110.
    Abstract:
    Soft tissue uptake is a rare finding in bone scintigraphy, with an incidence of 2%. Although the mechanism has not yet been fully clarified, several causes have been reported for this unusual uptake pattern. This paper presents a case of diffuse myocardial accumulation of technetium-99m hydroxymethylene diphosphonate ((99m)Tc-HDP) without either solid/visceral organ or soft tissue with multiple myeloma (MM) in skeletal scintigraphy. A 93-year-old man with hypertension and chronic heart failure for 14 years underwent bone scanning due to a 2-month history of back pain within a 1-year period of MM. Three hours later, (99m)Tc-HDP late static images showed diffuse myocardial radiotracer accumulation and there were no other sites of abnormal soft tissue or visceral uptake. Myocardial accumulation had disappeared on 24-h delayed static images. This accumulation was thought to be related with AL-type amyloidosis associated with MM.
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