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  • Title: Serum osteocalcin is associated with dietary vitamin D, body weight and serum magnesium in postmenopausal women with and without significant coronary artery disease.
    Author: Alissa EM, Alnahdi WA, Alama N, Ferns GA.
    Journal: Asia Pac J Clin Nutr; 2014; 23(2):246-55. PubMed ID: 24901094.
    Abstract:
    Osteoporosis and atherosclerosis often present atypically in postmenopausal women, making clinical recognition difficult. Prospective studies suggest independent associations between bone mass and vascular calcification through vitamin D deficiency as an established predictor of both conditions. We aimed to examine the relationship between serum osteocalcin and vitamin D status in postmenopausal women with and without angiographic evidence of coronary artery disease (CAD). One hundred and eighty postmenopausal women undergoing coronary angiography were selected sequentially from the Catheterization unit of King Abdulaziz University Hospital. Socio-demographic, anthropometric parameters and dietary habits were measured. Biochemical variables were estimated in blood samples. Half of the postmenopausal women did not have significant CAD, 24% had significant CAD in a single and/or double coronary vessels, 26% had significant CAD in three coronary vessels. Mean serum vitamin D concentrations showed that vitamin D deficiency was a common finding in the whole population. Vitamin D and calcium intakes were uniformly low in the study cohort. Serum osteocalcin was significantly correlated with dietary vitamin D in all subgroups (r=-0.172, p<0.05) and positively correlated among the patients (r=0.269, p=0.01). Serum magnesium, alkaline phosphatase, dietary vitamin D, and body weight were independent variables of serum osteocalcin level. In conclusion, elevated levels of serum C reactive protein and vitamin D were associated with low serum osteocalcin levels. Therefore, osteocalcin may be a potential cardiovascular risk marker. However, further studies are needed to clarify the pathophysiological processes underlying the relationship between serum osteocalcin level and atherosclerosis parameters. 骨质疏松和动脉粥样硬化在绝经后妇女中的表现往往不典型，使临床识别困难。前瞻性研究表明：维生素D 缺乏是骨量和血管钙化之间相关性的预测指 标。我们的研究目的是验证绝经后妇女的血清骨钙素和维生素D 状态之间的 关系，通过造影确诊这些妇女有无冠状动脉疾病(CAD)。从阿卜杜勒阿齐兹国 王大学医院征集了180 名接受冠状动脉造影的绝经后妇女。收集其社会人口学 指标、人体测量指标和饮食习惯，测定血中的生化指标。有一半的绝经后妇女 没有明显的CAD，24%的妇女单侧和/或双侧冠状血管有明显的CAD，26%的 妇女三条冠状血管均有明显的CAD。平均血清维生素D 浓度表明维生素D 缺 乏在所有人群中很常见。在研究人群中，维生素D 和钙的摄入量均低。在所 有亚组中，血清骨钙素与膳食维生素D 显著负相关(r=-0.172, p<0.05)，而在患 者中成正相关(r=0.269, p=0.01)。血清镁、碱性磷酸酶、膳食维生素D 和体重 是血清骨钙素水平的独立变量。总之，血清C 反应蛋白和维生素D 水平的升 高与血清骨钙素水平降低有关。因此，骨钙素可能是潜在的心血管风险的标志 物。然而，澄清血清骨钙素水平和动脉粥样硬化参数之间关系可能的病例生理 过程还需要进一步的研究。
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