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  • Title: Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization: access to CF3-containing 2-azaspiro[4.5]decanes.
    Author: Han G, Liu Y, Wang Q.
    Journal: Org Lett; 2014 Jun 20; 16(12):3188-91. PubMed ID: 24901480.
    Abstract:
    Copper-catalyzed intramolecular trifluoromethylation of N-benzylacrylamides coupled with dearomatization was achieved and used to regiospecifically construct a variety of trifluoromethylated 2-azaspiro[4.5]decanes bearing adjacent quaternary stereocenters under mild conditions in moderate to excellent yields.
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