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  • Title: Molecular evidence of Wolbachia endosymbiosis in Mansonella perstans in Gabon, Central Africa.
    Author: Gehringer C, Kreidenweiss A, Flamen A, Antony JS, Grobusch MP, Bélard S.
    Journal: J Infect Dis; 2014 Nov 15; 210(10):1633-8. PubMed ID: 24903665.
    Abstract:
    The discovery of obligatory intracellular bacteria of the genus Wolbachia in filariae infecting humans led to the use of antibiotics as a potent treatment option. Mansonella perstans is the cause of the second most prevalent filariasis in Gabon, but so far reports on the presence of Wolbachia in this nematode have been inconsistent. We report on the presence of Wolbachia in M. perstans in patients from Gabon, which we identified using polymerase chain reaction (PCR) with primer sets specific for 16S rDNA and ftsZ. Sequence analysis revealed a single consensus sequence, which could be phylogenetically assigned to Wolbachia of the supergroup F. Wolbachia could only be identified in 5 of 14 or 7 of 14 cases, depending on the investigated gene; detection of Wolbachia was associated with higher-level filaremia. Before generalizing the use of antibiotics for mansonellosis, further clarification of the obligatory nature of the endosymbiosis in this nematode is needed.
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