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  • Title: Drinking of flavored solutions by high preferring (WHP) and low preferring (WLP) alcohol-drinking rats.
    Author: Dyr W, Wyszogrodzka E, Mierzejewski P, Bieńkowski P.
    Journal: Pharmacol Rep; 2014 Feb; 66(1):28-33. PubMed ID: 24905303.
    Abstract:
    BACKGROUND: Selective breeding alcohol-preferring (P) and alcohol-nonpreferring (NP) rats showed a strong preference for the sucrose solutions, whereas P rats intake greater amounts than NP rats. The aim of this study was the estimation of selectively bred ethanol-preferring (WHP - Warsaw High Preferring) and ethanol-nonpreferring (WLP - Warsaw Low Preferring) rats for their preference for various tastes. METHODS: The oral drinking of the following substances was studied at a range of concentrations: sucrose (0.5-64.0 g/100 ml), NaCl (0.025-3.2 g/100 ml), citric acid (0.008-2.048 g/l), and sucrose octaacetate (0.002-0.512 g/l) solutions. Separate groups of 7-8 rats from each line were investigated of each of the four tastes. The investigated solutions were presented continuously keeping water and food always available. Concentrations of the various flavors were doubled every 48 h. RESULTS: Rats from WHP and WLP lines clearly revealed the preference for the sucrose solution and the highest preference was at the 4.0 and 8.0 g/100ml sucrose concentration. Similar to sucrose, both lines exposed strong preference for the NaCl solution and this preference enhanced together with the increase of the NaCl concentration. Nevertheless their preference for the NaCl solutions decreased when the concentration of NaCl reached 1.600 g/100 ml. Both lines of rats did not differ in citric acid or sucrose octaacetate intake at any of the concentrations studied. CONCLUSION: Selective breeding of rats (WHP) for high and rats (WLP) for low ethanol drinking is favorably correlated with the drinking of sweet and salty solutions and negatively correlated with the consumption of sour and bitter tastes.
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