These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Spectrophotometric determination of pefloxacin in pharmaceutical preparations.
    Author: Jelikić-Stankov M, Veselinović D, Malesev D, Radović Z.
    Journal: J Pharm Biomed Anal; 1989; 7(12):1571-7. PubMed ID: 2490545.
    Abstract:
    It has been established that the antibiotic pefloxacin (Abaktal) methanesulphonate reacts with Fe(III) at pH 1.00-8.00 to form a water-soluble complex with maximum absorbance at 360 nm. The composition of the complex, determined spectrophotometrically by the application of Job's, molar-ratio and Bent-French's methods, was pefloxacin: Fe(III) = 1:1 (pH = 2.50; lambda = 360 nm; mu = 0.1 M). The relative stability constant, obtained by the methods of Sommer and Asmus was 10(5.02) (pH = 2.50; lambda = 360 nm; mu = 0.1 M). The molar absorptivity of the complex at 360 nm was found to be 4.8 x 10(3) l mol-1 cm-1. Beer's law was followed for pefloxacin concentrations of 2.15-85.88 micrograms ml-1. The lower sensitivity limit of the method was 2.15 micrograms ml-1. The relative standard deviation (n = 10) was 0.57-1.07%. The method can be applied to the rapid and simple determination of pefloxacin in aqueous solutions and tablets.
    [Abstract] [Full Text] [Related] [New Search]