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  • Title: Berberine inhibits LPS-induced TF procoagulant activity and expression through NF-κB/p65, Akt and MAPK pathway in THP-1 cells.
    Author: Gao MY, Chen L, Yang L, Yu X, Kou JP, Yu BY.
    Journal: Pharmacol Rep; 2014 Jun; 66(3):480-4. PubMed ID: 24905527.
    Abstract:
    BACKGROUND: Considering the key role of TF in coagulation of sepsis or acute lung injury (ALI), we investigated whether berberine (BBR) could inhibit TF expression and procoagulant activity and explored its possible mechanism. METHODS: The effects of berberine on the expression, procoagulant activity of TF and related signal pathways induced by lipopolysaccharide (LPS) were observed in THP-1 cells. RESULTS: Our results showed that berberine could inhibit LPS-induced TF activity and expression, and down-regulate NF-κB, Akt and MAPK/JNK/p38/ERK pathways. CONCLUSION: Berberine inhibits TF expression and related pathway, which provides some new insights on its mechanism for sepsis treatment.
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