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  • Title: [Adenosine deaminase in pleural effusions. Its usefulness in the diagnosis of tuberculous pleurisy].
    Author: Pérez de Oteyza C, Chantres MT, Rebollar JL, Muñoz Yañez MC, García Marcos F, Pérez Barba M, Enríquez de Salamanca R.
    Journal: An Med Interna; 1989 May; 6(5):244-8. PubMed ID: 2491537.
    Abstract:
    The activity of adenosine deaminase was determined in 79 pleural effusions in order to evaluate the utility and reliability in diagnosing tuberculous effusions. The effusions were grouped by the etiology: 26 were tuberculous (group I); 22 were neoplastic (group II); 11 were pneumonic (group III); 10 were non-infections exudates of different causes (group IV); and 10 transudates (group V). Group I presented the higher median value of AD (MED = 81.92; DE: 29.02) the difference being statistically significant (p less than 0.0001) compared with the results of the other groups. We found 2 cases of pleural tuberculosis histologically demonstrated with AD levels under the amount of 40 U/L. In our experience, AD determination had a sensitivity of 92% and specificity of 94%; with a predictive value of 89% and a negative predictive value of 96%, this being considered useful but non specific of tuberculosis.
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