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  • Title: Update on nitroglycerin use.
    Author: Andrien P, Lemberg L.
    Journal: Heart Lung; 1989 Jan; 18(1):100-1. PubMed ID: 2492267.
    Abstract:
    Tolerance to nitrates occurs when this class of drugs is administered in a continuous around-the-clock regimen. Nitrate-free intervals from 10 to 12 hours are recommended to prevent nitrate tolerance. Full response with renewed administration occurs with interrupted nitrate therapy.
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