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  • Title: Regulation of B lymphocytes by natural killer cells. Role of IFN-gamma.
    Author: Michael A, Hackett JJ, Bennett M, Kumar V, Yuan D.
    Journal: J Immunol; 1989 Feb 15; 142(4):1095-101. PubMed ID: 2492576.
    Abstract:
    Using a co-culture system of fractionated B cells and highly purified NK cells, we have demonstrated direct interactions between B lymphocytes and NK cells. B cells are able to stimulate the production of IFN-gamma by NK cells. This stimulatory ability is restricted to a subpopulation of large, presumably in vivo activated B lymphocytes. The secreted IFN-gamma in turn inhibits polyclonally induced B cell proliferation. Small resting B cells neither stimulate IFN-gamma production nor are they measurably affected by NK cells.
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