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  • Title: Immunoglobulin light chains in common acute lymphoblastic leukaemia.
    Author: Markey GM, Alexander HD, Nolan RL, Morris TC, Robertson JH.
    Journal: Br J Haematol; 1989 Jan; 71(1):53-5. PubMed ID: 2492820.
    Abstract:
    A single immunoglobulin light chain lambda was identified in the blast cells of two out of 12 patients with common acute lymphoblastic leukaemia (C-ALL) using the alkaline phosphatase/anti-alkaline phosphatase (APAAP) technique. Inhibition at the cell surface proved that the reaction was a genuine anti-lambda reaction. Immunoglobulin mu chain was not identified in these patients. Results of immunoglobulin typing in 103 patients with B chronic lymphocytic leukaemia (B-CLL) are cited to show the increased sensitivity of the APAAP technique as compared to the indirect immunoperoxidase technique for cellular immunoglobulin identification.
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