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  • Title: Inhibin concentrations in the peripheral blood of rams during a cycle in testicular activity induced by changes in photoperiod or treatment with melatonin.
    Author: Lincoln GA, McNeilly AS.
    Journal: J Endocrinol; 1989 Jan; 120(1):R9-13. PubMed ID: 2493060.
    Abstract:
    Changes in the concentration of inhibin, FSH, LH and testosterone were measured in the peripheral blood of adult Soay rams during a reproductive cycle induced by exposure to an artificial lighting regimen (long days with a 16-week period of short days) or treatment with melatonin (long days with a 12-week period when melatonin was administered daily in mid-light phase to simulate the effect of short days). In both experimental situations, changes in the plasma concentrations of inhibin occurred in parallel with the cycle in the diameter of the testes with a four- to fivefold increase in the inhibin concentrations from the nadir to the peak of the testicular cycle. Increases in the plasma concentrations of FSH, LH and testosterone also occurred in association with the reactivation of the reproductive axis. The weekly changes in the plasma concentrations of inhibin were positively correlated with the changes in plasma FSH values during the developing and regressing stages of the testicular cycle but negatively correlated during the active stage. In a group of castrated rams exposed to the same lighting regimen, the plasma concentrations of inhibin were always below the detection limit of the radioimmunoassay. The testosterone values were also very low in the castrates while the plasma concentrations of FSH and LH were 10-50 fold higher than normal and varied in relation to the light cycle. The results show for the first time that inhibin is secreted into the peripheral blood in the ram exclusively from the testes.(ABSTRACT TRUNCATED AT 250 WORDS)
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