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  • Title: An inhibition model of BPTI to unlinked dengue virus NS2B-NS3 protease.
    Author: Li H, Zhu L, Hou S, Yang J, Wang J, Liu J.
    Journal: FEBS Lett; 2014 Aug 25; 588(17):2794-9. PubMed ID: 24931377.
    Abstract:
    One approach to treating the dengue virus infection is to inhibit its NS2B-NS3 protease that plays a vital role in virus maturation. However, the lack of structural information on the active conformation of the protease hindered related drug design. With a co-expression system, we obtained the active two-component protease in its unlinked form. BPTI shows strong competitive inhibitory activity (Ki = 6.5 nM) against this unlinked protease, which adopts a closed conformation. Based on the biochemical and NMR perturbation information, an inhibition model of BPTI to NS2B-NS3 protease is proposed.
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