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  • Title: IgM gammopathy and polyneuropathy react with an antigenic glycolipid present in human central nervous system.
    Author: Jauberteau MO, Younes-Chennoufi B, Rigaud M, Baumann N.
    Journal: Neurosci Lett; 1989 Feb 13; 97(1-2):181-4. PubMed ID: 2493142.
    Abstract:
    An immunological mechanism may be responsible for the peripheral neuropathies associated with the IgM monoclonal gammopathies. Myelin-associated glycoprotein, and sulfated glucuronic acid-glycosphingolipids of the paragloboside type specific of peripheral nervous system (PNS), have been found to be targets for these antibodies. We report here on the presence of a glycolipid antigen present in central nervous system white matter in 7 of 12 patients with IgM monoclonal gammopathy and neuropathy whose IgM reacts also with the specific sulfated glycolipids of PNS. Immunodetection of the antibodies was performed on thin-layer plates after separation of the glycosphingolipids from peripheral nerve and white matter. The lipid antigen had a migration on thin-layer chromatography close to sulfogalactosylceramide but the sulfatide standard did not react with the monoclonal IgM.
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