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  • Title: [Long-term results following surgery or radioiodine treatment of solitary autonomous adenoma of the thyroid gland].
    Author: Müller-Gärtner HW, Schneider C, Riechert B, Kayser D, Kremer B.
    Journal: Chirurg; 1989 Jan; 60(1):33-7. PubMed ID: 2493360.
    Abstract:
    128 patients were investigated after surgery (n = 72) or 131-iodine therapy (n = 56) of a scintigraphically solitary, hyperfunctioning adenoma of the thyroid gland. The median follow-up period amounted to 10.6 years. Recurrent hyperthyroidism was observed in six patients after surgery and in one patient after 131-iodine therapy. Hypothyroidism occurred in one patient after 131-iodine therapy. The percentage of 131-iodine treated patients with a normal TSH-response to TSH-releasing hormone (TRH) increased during the follow-up period from 57 to 90%, whereas after surgery the percentage of patients showing a normal TSH-response to TSH decreased from 58 to 31%. This latter observation points to persistent hyperfunctioning tissue areas inducing late recurrent hyperthyroidism in 8.3% of the patients who underwent surgery.
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