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  • Title: From neuraminidase inhibitors to conjugates: a step towards better anti-influenza drugs?
    Author: Cheng CK, Tsai CH, Shie JJ, Fang JM.
    Journal: Future Med Chem; 2014 May; 6(7):757-74. PubMed ID: 24941871.
    Abstract:
    For the treatment of seasonal flu and possible pandemic infections the development of new anti-influenza drugs that have good bioavailability against a broad spectrum of influenza viruses including the resistant strains is needed. In this review, we summarize previous methods for the structural modification of zanamivir, a potent neuraminidase inhibitor that has rare drug resistance, in order to develop effective anti-influenza drugs. We also report recent research into the design of multivalent zanamivir drugs and bifunctional zanamivir conjugates, some of which have shown better efficacy in animal experiments. As a step towards developing improved antivirals, conjugating anti-influenza drugs with anti-inflammatory agents can improve oral bioavailability and also exert synergistic effect in influenza therapy.
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