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  • Title: Sarcolipin provides a novel muscle-based mechanism for adaptive thermogenesis.
    Author: Gamu D, Bombardier E, Smith IC, Fajardo VA, Tupling AR.
    Journal: Exerc Sport Sci Rev; 2014 Jul; 42(3):136-42. PubMed ID: 24949847.
    Abstract:
    The sarco(endo)plasmic reticulum Ca-ATPase (SERCA) transports Ca into the sarcoplasmic reticulum lumen and contributes significantly to skeletal muscle metabolic rate. Sarcolipin (SLN) has been shown recently to uncouple Ca transport from adenosine triphosphate hydrolysis by SERCA. We have hypothesized that SLN provides a novel mechanism of adaptive thermogenesis within skeletal muscle and protects against diet-induced obesity.
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