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  • Title: Hypotensive effect of retabolil correcting the concentration of aldosterone during stress exposures.
    Author: Obut TA, Ovsyukova MV, Egorova SA, Erdynieva TA, Dement'eva TY, Obut ET, Gorobchuk AG.
    Journal: Bull Exp Biol Med; 2014 Jun; 157(2):231-3. PubMed ID: 24952492.
    Abstract:
    Male rats were exposed to single or repeated (19 days) cold treatment (4°C) and non-cold stress (60-min shaking on a laboratory shuttle device). Retabolil had a hypotensive effect, which was accompanied by the prevention of a stress-induced increase in the concentration of a hypertensive hormone aldosterone. Under conditions of repeated stress, these effects were realized via μ-opioid receptors. Our results suggest that retabolil can be used as a hypotensive and aldosterone-blocking agent, at least during stress exposure in animals (and probably in humans).
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