These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Exploring bis(cyclometalated) ruthenium(II) complexes as active catalyst precursors: room-temperature alkene-alkyne coupling for 1,3-diene synthesis.
    Author: Zhang J, Ugrinov A, Zhang Y, Zhao P.
    Journal: Angew Chem Int Ed Engl; 2014 Aug 04; 53(32):8437-40. PubMed ID: 24954299.
    Abstract:
    Described is the development of a new class of bis(cyclometalated) ruthenium(II) catalyst precursors for C-C coupling reactions between alkene and alkyne substrates. The complex [(cod)Ru(3-methallyl)2] reacts with benzophenone imine or benzophenone in a 1:2 ratio to form bis(cyclometalated) ruthenium(II) complexes (1). The imine-ligated complex 1 a promoted room-temperature coupling between acrylic esters and amides with internal alkynes to form 1,3-diene products. A proposed catalytic cycle involves C-C bond formation by oxidative cyclization, β-hydride elimination, and C-H bond reductive elimination. This Ru(II)/Ru(IV) pathway is consistent with the observed catalytic reactivity of 1 a for mild tail-to-tail methyl acrylate dimerization and for cyclobutene formation by [2+2] norbornene/alkyne cycloaddition.
    [Abstract] [Full Text] [Related] [New Search]