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  • Title: Analysis of nucleic acid-induced nonimmune cell death in vitro.
    Author: Romoli S, Migliorini A.
    Journal: Methods Mol Biol; 2014; 1169():77-86. PubMed ID: 24957231.
    Abstract:
    Foreign nucleic acids are recognized by germ-line-encoded receptors expressed in immune and nonimmune cells. Activation of the nucleic acid-specific pattern recognition receptors by foreign nucleic acid promotes production of inflammatory cytokines (mostly type I IFNs) and at the later stage leads to cell death. Here, we describe reliable and simple methods to quantify cell death caused by nucleic acid recognition. Additionally, we report two different methods to discriminate between two cell death modalities: apoptosis and necrosis.
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