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  • Title: Spin90 deficiency increases CXCL13-mediated B cell migration.
    Author: Park SH, Kim HR, Jun CD, Song WK, Park SG.
    Journal: Scand J Immunol; 2014 Sep; 80(3):191-7. PubMed ID: 24965518.
    Abstract:
    SPIN90 regulates actin dynamics, which is important for cell migration control. CXCL13-mediated B cell migration is essential for B cell immune responses. In this study, we investigated the role of SPIN90 in CXCL13-mediated B cell migration using Spin90 gene-deficient mice. Our chemokinesis analysis and transwell cell migration assay showed that SPIN90 is involved in CXCL13-mediated B cell migration. Moreover, the level of CXCR5, which is CXCL13 receptor, was increased in SPIN90-deficient B cells compared with wild-type B cells. Overall, our data suggest that SPIN90 plays an important role in B cell immune responses through the regulation of CXCL13-mediated B cell migration.
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