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  • Title: Evidence for the induction of cytochrome P-452 in rat liver by Aroclor 1254, a commercial mixture of polychlorinated biphenyls.
    Author: Borlakoglu JT, Edwards-Webb JD, Dils RR, Wilkins JP, Robertson LW.
    Journal: FEBS Lett; 1989 Apr 24; 247(2):327-9. PubMed ID: 2497034.
    Abstract:
    We have examined the ability of a commercial mixture of polychlorinated biphenyls (Aroclor 1254) to induce hepatic cytochrome P-452-linked enzyme activities in rat and pigeon liver five days after its intraperitoneal injection. The results provide evidence that, at the doses used, Aroclor 1254 induces cytochrome P-452-linked enzyme activities in rats, but not in pigeons. This inductive effect was previously regarded as being specific for hypolipidemic drugs and phthalate ester plasticisers.
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