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  • Title: Ovulation induction with clomiphene citrate and metformin in women with polycystic ovary syndrome.
    Author: Leanza V, Coco L, Grasso F, Leanza G, Zarbo G, Palumbo M.
    Journal: Minerva Ginecol; 2014 Jun; 66(3):299-301. PubMed ID: 24971785.
    Abstract:
    AIM: Polycystic ovary syndrome (PCOS) is one of the most common causes of ovulatory infertility. It is an endocrine disorders characterized by a high level of male hormones (androgens) and frequent anovulatory cycles associated with multiple ovarian microcysts. The aim of this paper was to evaluate effects of a Clomiphene citrate alone versus a combined treatment (Metformin and Clomiphene citrate). METHODS: A total of 60 women with PCOS and infertility were evaluated. Inclusions criteria were: age 26-34 years, nulliparity, above 3 years of sterility, multiple ovarian microcysts, BMI>27.5, oligomenorrhea/amenorrhea, hyperandrogenism and normal male fertility. Four patients were excluded (renal damage 2, tubal occlusion 1 and Pelvic Inflammatory Disease 1). The remaining 56 were divided into 2 groups: group A were inducted with Clomiphene Citrate alone, while group B were inducted with Clomiphene citrate and Metformin. RESULTS: In group A we obtained ovulation in 20 women (71.4%), 8 pregnancies (28.5%) and one (3.5%) spontaneous abortion. In group B we obtained ovulation in 24 women (85.7%), 15 pregnancies (53.5%) and no spontaneous abortions. CONCLUSION: Combined treatment was found to be more effective (53.5) in improving pregnancy rate compared to monotherapy (28.5%).
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