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  • Title: [Canthaxanthin retinopathy without intake of canthaxanthin].
    Author: Oosterhuis JA, Remky H, Nijman NM, Craandijk A, de Wolff FA.
    Journal: Klin Monbl Augenheilkd; 1989 Feb; 194(2):110-6. PubMed ID: 2497265.
    Abstract:
    Seven patients are described who presented with the typical fundus finding of gold-colored crystals in the superficial layers of retina in the macular area (characteristic of canthaxanthin retinopathy) without having taken canthaxanthin-containing drugs. Canthaxanthin used as a food additive is discussed as a possible cause of the crystal deposition. There may be a rather high individual tendency to develop crystal deposition, possibly related to a metabolic defect affecting canthaxanthin kinetics or to pre-existing changes in the retinal pigment epithelium. In one patient a slight decrease in crystalline deposition was observed in the course of four years.
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