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  • Title: Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety.
    Author: Baldwin HA, File SE.
    Journal: Psychopharmacology (Berl); 1989; 97(3):424-6. PubMed ID: 2497494.
    Abstract:
    Rats were chronically treated with chlordiazepoxide (CDP 10 mg/kg/day) or vehicle for 27 days. Twenty-four hours after their last dose, they received flumazenil (4 mg/kg) or vehicle and were tested in the social interaction test, in a low-light, familiar arena. CDP withdrawal significantly reduced the time spent in social interaction compared with controls, indicating an anxiogenic withdrawal response. This was completely reversed by flumazenil. A second group received CDP for 27 days and, in addition, received a single dose of flumazenil (4 mg/kg) 6 days before testing. Flumazenil prevented the development of the anxiogenic withdrawal response in these rats.
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