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  • Title: Cytotoxic triterpenoids from Saussurea phyllocephala.
    Author: Hu J, Song Y, Yang B, Zuo X, Mao X, Shi X.
    Journal: Arch Pharm Res; 2014 Dec; 37(12):1515-21. PubMed ID: 24975046.
    Abstract:
    Three new triterpenoids, 11α-hydroxy-lup-20(29)-ene-3β-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3β-palmitate (2), and 1β,11α,28-tyrihydroxy oleana-9(11),12-dien-3β-palmitate (3), together with three known compounds were isolated from the 95 % EtOH extract of Saussurea phyllocephala. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. All the triterpenoids were in vitro evaluated for their cytotoxic activities. Compound 1-3 exhibited the significant cytotoxic activities with low IC50 values (IC50 < 4.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).
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