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  • Title: The importance of phospholipase A2 in the early induction by crotoxin of biphasic changes in endplate potentials at the frog neuromuscular junction.
    Author: Hawgood BJ, Smith IC.
    Journal: Toxicon; 1989; 27(2):272-6. PubMed ID: 2497559.
    Abstract:
    In Ca2+-Ringer, crotoxin induced a rapid fall in amplitude of endplate potentials followed by a marked secondary rise but, in Ca2+-free, Sr2+-EGTA Ringer, crotoxin failed to elicit either response. In Ca2+-washout experiments, the onset of giant miniature endplate potentials indicated that binding of crotoxin occurred in Sr2+-EGTA Ringer. Facilitation of endplate potential amplitude due to a closely spaced twin impulse was increased to 162% of control near the peak of the crotoxin-induced secondary phase. These findings are consistent with the phospholipase A2 subunit acting specifically at the active zone.
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