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  • Title: Chemistry of silybin.
    Author: Biedermann D, Vavříková E, Cvak L, Křen V.
    Journal: Nat Prod Rep; 2014 Sep; 31(9):1138-57. PubMed ID: 24977260.
    Abstract:
    Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared.
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