These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of striatal implantation of bovine adrenal chromaffin cells on turning behavior in a rat model of Parkinson's disease.
    Author: Fitzgerald LR, Glick SD, Schneider AS.
    Journal: Brain Res; 1989 Mar 06; 481(2):373-7. PubMed ID: 2497928.
    Abstract:
    Rats lesioned unilaterally with 6-hydroxydopamine, as an animal model of Parkinson's disease, were tested for D-amphetamine-induced rotation. Buffer or isolated bovine adrenal chromaffin cells were implanted into the lesioned striatum. Rats were retested for rotation 1 and 4 weeks postimplantation. Those with surviving implants rotated significantly less than controls. HPLC assay of striata showed that implants contained elevated norepinephrine and epinephrine, but not dopamine. The results show that the bovine chromaffin cell implants can function as a restorative treatment for nigrostriatal damage, that neonatal implants work better than adult implants, and that such restoration occurs independent of dopamine levels.
    [Abstract] [Full Text] [Related] [New Search]