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  • Title: Copper-catalyzed direct C-2 difluoromethylation of furans and benzofurans: access to C-2 CF2H derivatives.
    Author: Belhomme MC, Poisson T, Pannecoucke X.
    Journal: J Org Chem; 2014 Aug 01; 79(15):7205-11. PubMed ID: 24979681.
    Abstract:
    We report herein the first copper-catalyzed C-2 difluoromethylation of furans and benzofurans. The developed methodology allows the selective introduction of the CF2CO2Et moiety at C-2 using CuI as a catalyst. This process was applied to a broad range of furans and benzofurans, giving the functionalized products in moderate to good yields. The resulting products were then decarboxylated to afford the highly valuable C-2-CF2H-substituted furans and benzofurans in good yields.
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