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  • Title: The use of purified clotting factor concentrates in hemophilia. Influence of viral safety, cost, and supply on therapy.
    Author: Pierce GF, Lusher JM, Brownstein AP, Goldsmith JC, Kessler CM.
    Journal: JAMA; 1989 Jun 16; 261(23):3434-8. PubMed ID: 2498537.
    Abstract:
    Treatment of hemophilia, although greatly improved in recent years, continues to be problematic owing to infectious complications of blood product replacement therapy. This report examines the therapeutic options presently available for the treatment of hemophilia, focusing on the potential for repeated viral exposure to influence the progression of infectious disease, decreased risks of viral transmission with blood products produced using newer viral inactivation procedures, higher economic costs of newer blood products, and the current inadequate supply of blood products in the United States.
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