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  • Title: [Deposition of light chains in various organs; light chain deposition disease].
    Author: van Klaveren RJ, Holdrinet RS, Assmann KJ.
    Journal: Ned Tijdschr Geneeskd; 1989 May 06; 133(18):943-6. PubMed ID: 2498673.
    Abstract:
    The case is reported of a patient with renal insufficiency, proteinuria and heart failure caused by 'light chain deposition disease' (LCDD). A renal biopsy showed nodular glomerulosclerosis, IF examination revealed linear deposits of monoclonal lambda light chains along the glomerular and tubular basement membranes. Similar deposits could be shown in a skin biopsy. No light chains could be detected in urine and serum. The patient had a good response to treatment with melphalan and prednisone.
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